Bisarylimidazolyl fatty acid amide hydrolase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 233/61 (2006.01) A61K 31/4164 (2006.01) A61K 31/4174 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 233/54 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2445294

The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said compounds inhibiting fatty acid amide hydrolase and useful for the treatment of pain, particularly neuropathic pain, psychomotor disorder, hypertension, cardiovascular disease, eating disorder, nausea, AIDS-related complex, glaucoma, inflammation, psoriasis or multiple sclerosis, and other conditions the treatment of which can be effected by inhibiting fatty acid amide hydrolase.

L'invention porte sur des dérivés du bisarylimidazolyle et sur des préparations pharmaceutiques comprenant lesdits composés qui inhibent l'hydrolase des amides d'acides gras et servent au traitement de la douleur, particulièrement à caractère neuropathique, des troubles psychomoteurs, de l'hypertension, des maladies cardio-vasculaires, des troubles de l'alimentation, des nausées, du complexe associé au SIDA, du glaucome, des inflammations, du psoriasis et de la sclérose en plaques, et autres états traitables par l'inhibition de l'hydrolase des amides d'acides gras.

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