Bisarylurea derivatives useful for inhibiting chk1

Details Bisarylurea derivatives useful for inhibiting chk1 Bisarylurea derivatives useful for inhibiting chk1

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4965 (2006.01) A61P 35/00 (2006.01) C07D 241/20 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2571424

Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed. Formula (I).

L~invention décrit des composés d'urée à substitution aryle et hétéroaryle utiles dans le traitement de maladies et de conditions liées à l~endommagement ou aux lésions de l'ADN au cours de la réplication de l'ADN. Des procédés de fabrication des composés, et leur utilisation comme agents thérapeutiques, par exemple, dans le traitement du cancer et autres maladies caractérisées par des défauts de réplication de l'ADN, une ségrégation des chromosomes, ou une division cellulaire sont également décrits. Formule (I).

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