Bisoprolol-containing adhesive patch

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/138 (2006.01) A61K 9/70 (2006.01) A61K 47/10 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2633125

A bisoprolol-containing adhesive patch which comprises a support and an adhesive layer superposed on one side thereof. The adhesive layer is characterized by comprising a branched C12-28 monohydric alcohol, a free bisoprolol base, and a polyisobutylene-based pressure-sensitive adhesive. In this constitution, the compatibility between the polyisobutylene-based pressure-sensitive adhesive and the free bisoprolol base can be specifically heightened. As a result, it is possible to incorporate the free bisoprolol base in a large amount. The pressure-sensitive adhesive layer can be inhibited from suffering the bleeding of the free bisoprolol base and have practically sufficient pressure-sensitive adhesive properties.

La présente invention se rapporte à un timbre adhésif contenant du bisoprolol, qui comprend un support et une couche adhésive superposée sur une face dudit support. La couche adhésive est caractérisée en ce qu'elle contient un alcool monohydrique ramifié C12-28, une base libre de bisoprolol, et un adhésif autocollant à base de polyisobutylène. Dans ladite configuration, la compatibilité entre l'adhésif autocollant à base de polyisobutylène et la base libre de bisoprolol peut être spécifiquement améliorée, ce qui permet d'incorporer la base libre de bisoprolol en grande quantité. La couche adhésive autocollante peut être protégée contre la migration de la base libre de bisoprolol et présenter des propriétés adhésives autocollantes suffisantes dans la pratique.

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