C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2544562
A bispecific antibody comprising two antibody variable domains on a single polypeptide chain, wherein a first portion of the bispecific antibody is capable of recruiting the activity of a human immune effector cell by specifically binding to an effector antigen on the human immune effector cell, said first portion consisting of one antibody variable domain, and a second portion of the bispecific antibody specifically binds to a target antigen other than the effector antigen, said target antigen on a target cell other than said human immune effector cell, and said second portion comprising one antibody variable domain.
L'invention concerne un anticorps bispécifique comprenant deux domaines variables d'anticorps sur une seule chaîne polypeptidique. Une première partie de l'anticorps bispécifique est capable de recruter l'activité d'une cellule effectrice immunitaire humaine par fixation spécifique sur un antigène effecteur sur la cellule effectrice immunitaire humaine, la première partie comportant un domaine variable d'anticorps. Une seconde partie de l'anticorps bispécifique se fixe de manière spécifique à un antigène cible autre que l'antigène effecteur, ledit antigène cible sur une cellule cible autre que ladite cellule effectrice immunitaire humaine, et ladite seconde partie comprenant un domaine variable d'anticorps.
Baeuerle Patrick
Berry Meera
Itin Christian
Kufer Peter
Micromet Ag
Smart & Biggar
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