C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61P 3/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2534898
The bispecific antibodies of the present invention are in the form of a heteroconjugate that inhibits growth and induces apoptosis of a diseased cell and that does not require the recruitment of effector cells. The heteroconjugate has at least two binding arms wherein each of the binding arms possesses a different specificity and need not have apoptotic activity when not conjugated to each other. Also provided are methods of treating and diagnosing a diseased cell using the bispecfic antibodies of the present invention.
Les anticorps bispécifiques selon la présente invention se présentent sous la forme d'un hétéroconjugué qui inhibe la croissance et induit l'apoptose d'une cellule malade et qui ne nécessite pas le recrutement de cellules effectrices. Ledit hétéroconjugué présente au moins deux bras de liaison, chacun des bras de liaison possédant une spécificité différente et ne devant pas présenter une activité apoptotique lorsqu'il n'est pas conjugué à l'autre. L'invention concerne également des méthodes de traitement et de diagnostic d'une cellule malade faisant appel aux anticorps bispécifiques selon la présente invention.
Goldenberg David M.
Hansen Hans J.
Horak Eva
Horak Ivan
Hsing-Chang Chien
Immunomedics Inc.
Smart & Biggar
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