Bispecific antibodies that bind to vegf receptors

Details Bispecific antibodies that bind to vegf receptors Bispecific antibodies that bind to vegf receptors

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2452058

The present invention is directed to production of antigen-binding proteins that bind specifically to an extracellular domains of two different VEGF receptors, The bispecific antigen-binding proteins block activation of the VEGF receptors and are used to reduce or inhibit VEGF-induced cellular functions such as mitogenesis of vascular endothelial cells and migration of leukemia cells. The antigen-binding proteins of the present invention can be monovalent or multivalent, have antigen-binding sites consisting of immunoglobulin heavy chain and light chain variable domains and may further include immunoglobulin constant domains.

L'invention porte sur la production de protéines de liaison d'antigènes se liant spécifiquement à un domaine extracellulaire de deux récepteurs VEGF différents. Les protéines de liaison d'antigènes bispécifiques bloquent l'activation des récepteurs VEGF et servent à réduire ou inhiber les fonctions cellulaires induites par VEGF, dont la mitogenèse de cellules endothéliales vasculaires et la migration de leucocytes. Les protéines de liaison d'antigènes de cette invention peuvent être monovalentes ou multivalentes, présentent des sites de liaison d'antigènes constitués de domaines variables à chaîne lourde et à chaîne légère d'immunoglobuline et peuvent comprendre en outre des domaines constants d'immunoglobuline.

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