Bispecific antibody determinants

Details Bispecific antibody determinants Bispecific antibody determinants

C - Chemistry, Metallurgy

07

K

324/23, 167/43,

C07K 16/46 (2006.01) G01N 33/531 (2006.01) G01N 33/533 (2006.01) G01N 33/577 (2006.01)

Patent

CA 1338828

A method of preparing a bispecific monoclonal antibody determinant comprising the steps of providing two different monoclonal antibody determinants, each determinant comprising two identical L-H half-molecules linked by one or more disulfide bond, subjecting the two different antibody determinants to conditions sufficient to break the disulfide bonds linking the L-H half-molecules, whereby each determinant is split into a pair of identical half-molecules, derivatizing one pair of identical half-molecules with a thiol activating agent, and combining the half-molecules to form the bispecific antibody determinants by the formation of one or more disulfide bonds.

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