C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2416572
The present invention relates to the stimulation of APO-1--dependent cell death only in specific target cells using a bispecific antibody that binds APO-1 and a target cell-specific antigen. Specifically, there is a bispecific antibody fragment which is lacking an Fc moiety wherein the antibody fragment has a monovalent binding side for a death receptor and a binding site for a target antigen wherein the death receptor is APO-1 and the target antigen is selected from the group consisting of tumor cell-specific cell surface antigens, T-cell specific cell surface antigens, CD markers and cell-specific markers.
Un réactif multispécifique (15) présente au moins une première zone de liaison (17) destinée à un récepteur de surface cellulaire (12) dont la stimulation nécessite une liaison de ligands multimère. Le réactif (15) présente une deuxième zone de liaison (16) destinée à un antigène cible (14) exprimé sur la même cellule (10) que le récepteur de surface cellulaire (12).
Jung Gundram
Sim & Mcburney
LandOfFree
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