Bispecific antibody point mutations for enhancing rate of...

Details Bispecific antibody point mutations for enhancing rate of... Bispecific antibody point mutations for enhancing rate of...

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/30 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2478011

A mutant bispecific antibody that includes (a) a human hinge constant region from IgG having one or more amino acid mutations in the CH2 domain, (b) two SCFVS; and (c) two FVS has been constructed. This type of antibody displays enhanced clearance, which has been found to be particularly useful in the context of pre-targeting methods.

L'invention concerne un anticorps bispécifique mutant comprenant (a) une région constante charnière humaine d'IgG comportant une ou plusieurs mutations d'acides aminés dans le domaine Ch2, (b) deux scFvs, et (c) deux Fvs. Ce type d'anticorps présente une clairance améliorée, ce qui s'avère être particulièrement utile dans le contexte de méthodes de pré-ciblage.

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