Bispecific antisense oligonucleotides that inhibit igfbp-2...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2469685

Bispecific antisense oligonucleotides which consist essentially of a sequence of bases that is complementary to portions of both the gene encoding human IGFBP-2 and the gene encoding human IGFBP-5 are useful in as antisense therapeutics in the treatment of endocrine-regulated cancers.

L'invention concerne des oligonucléotides antisens bispécifiques comprenant essentiellement une séquence de bases complémentaire aux parties à la fois du gène codant l'IGFBP-2 humain et du gène codant l'IGFBP-5 humain utiles en tant que substances thérapeutiques antisens dans le traitement de cancers à régulation endocrine.

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