Bispecific binding agents for modulating biological activity

Details Bispecific binding agents for modulating biological activity Bispecific binding agents for modulating biological activity

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2599606

Methods for improving the specific binding ability of bispecific binding compositions are described. The bispecific binding compositions are able to target cells by a high affinity targeting domain to a target cell surface marker and a low affinity binding domain that binds specifically to a second cell surface marker, wherein the binding of each domain to its respective cell surface marker increases or decreases, as desired, the biological activity of the respective cell surface markers. The invention further provides bispecific binding agents for use in the methods, as well as uses for the agents.

Cette invention concerne des procédés permettant d'améliorer la capacité de liaison bispécifique de compositions de liaison bispécifiques. Les compositions de liaison bispécifiques peuvent cibler des cellules par un domaine de ciblage à haute affinité sur un marqueur de surface de cellules cibles et un domaine de liaison à faible affinité qui se lie spécifiquement à un second marqueur de surface de cellules, la liaison de chaque domaine à son marqueur de surface de cellules respectif augmentant ou réduisant, selon les besoins, l'activité biologique des marqueurs de surface de cellules respectifs. Cette invention concerne également des agents de liaison bispécifiques utilisés dans les procédés, ainsi que des utilisations de ces agents.

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