Bispecific domain antibodies targeting serum albumin and...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/46 (2006.01) A61K 47/48 (2006.01) A61P 1/00 (2006.01) A61P 3/10 (2006.01) C07K 16/44 (2006.01)

Patent

CA 2589800

Drug fusions and conjugates that contain an incretin therapeutic or diagnostic agent that is fused or conjugated to an antigen-binding fragment of an antibody that binds serum albumin. The conjugates and fusion have a longer in vivo half life in comparison with the unconjugated or unfused therapeutic or diagnostic agent.

La présente invention a trait à des fusions et conjugués médicamenteux contenant un agent thérapeutique et diagnostique à base d'incrétine qui est fusionné ou conjugué à un fragment de liaison à l'antigène d'un anticorps de liaison à l'albumine sérique. Les conjugués et fusions ont une durée de vie plus longue in vivo comparés à l'agent thérapeutique ou diagnostique non conjugué ou non fusionné.

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