C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/78 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2744405
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
La présente invention concerne des molécules bispécifiques comportant un domaine de liaison EGFR et un domaine de liaison IGFIR distinct du premier pour emploi dans des applications diagnostiques, de recherche et thérapeutiques. La présente invention concerne en outre des cellules comportant de telles protéines, un polynucléotide codant de telles protéines ou leurs fragments et des vecteurs comprenant les polynucléotides codant les protéines selon l'invention. Les molécules bispécifiques exemplifiant l'invention incluent les dimères de protéines de type anticorps basés sur le dixième domaine de la fibronectine de type III.
Camphausen Ray
Carboni Joan
Emanuel Stuart
Engle Linda
Gottardis Marco
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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