Bispecific intracellular delivery vehicles

Details Bispecific intracellular delivery vehicles Bispecific intracellular delivery vehicles

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/00 (2006.01) A61K 47/34 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2742955

A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.

L'invention porte sur une composition destinée à administrer un agent à une cellule, comprenant un agent d'affinité bispécifique et un polymère de déstabilisation de membrane, sensible au pH. Le réactif d'affinité bispécifique peut comprendre un premier réactif d'affinité lié de manière covalente à un second réactif d'affinité, le premier réactif d'affinité se liant à une molécule sur la surface d'une cellule, et le second réactif d'affinité se liant à une cible intracellulaire.

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