Bispecific ligands with binding specificity to cell surface...

Details Bispecific ligands with binding specificity to cell surface... Bispecific ligands with binding specificity to cell surface...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 38/02 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2632424

Disclosed are ligands comprising a first polypeptide domain having a binding site with binding specificity for a first cell surface target and a second polypeptide domain having a binding site for a second cell surface target, wherein each target are different and on the same cell. In some embodiments, the ligands described further comprise a toxin. In other embodiments, the ligands further comprise half-life extending moieties. Also disclosed are methods of using these ligands. In particular, the use of these ligands for cancer therapy is described.

La présente invention concerne des ligands comprenant un premier domaine polypeptidique ayant un site de liaison avec une spécificité de liaison pour une première cible de surface cellulaire et un second domaine polypeptidique ayant un site de liaison pour une seconde cible de surface cellulaire, chaque cible étant différente et sur la même cellule. Dans certains modes de réalisation, les ligands décrits comprennent en outre une toxine. Dans d'autres modes de réalisation, les ligands comprennent en outre des groupes prolongeant la demi-vie. La présente invention décrit en outre des procédés d'utilisation de ces ligands. En particulier, l'utilisation de ces ligands pour la thérapie du cancer est décrite.

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