Bispecific molecules and uses thereof

Details Bispecific molecules and uses thereof Bispecific molecules and uses thereof

A - Human Necessities

61

K

A61K 39/00 (2006.01) C07K 16/08 (2006.01) C07K 16/12 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) C12N 5/24 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2405961

The present invention relates to bispecific molecules that are characterized by having a first binding domain which binds an antigen present in the circulation of a mammal and a second binding domain which binds the C3b-like receptor (known as complement receptor 1 (CR1) or CD35 in primates). The bispecific molecules do not consist of a first monoclonal antibody to CR1 that has been chemically cross-linked to a second monoclonal antibody. The invention also relates to methods of making the bispecific molecules and therapeutic uses thereof, as well as to kits containing the bispecific molecules. The invention further provides polyclonal populations of bispecific molecules, which comprise populations of bispecific molecules with different antigen recognition specificities. Such polyclonal populations of bispecific molecules can be used for targeting multiple epitopes of a pathogenic antigenic molecule and/or multiple variants of a pathogenic antigenic molecule.

L'invention concerne des molécules bispécifiques qui sont caractérisées par un premier domaine de liaison qui permet de lier un antigène présent dans le système circulatoire d'un mammifère avec un second domaine de liaison qui permet de lier le récepteur de type C3b (connu chez les primates en tant que récepteur 1 de complément (CR1) ou CD35). Les molécules bispécifiques ne consistent pas en un premier anticorps monoclonal à CR1 réticulé chimiquement à un second anticorps monoclonal. L'invention concerne aussi des procédés de fabrication des molécules bispécifiques, leurs utilisations thérapeutiques ainsi que des nécessaires contenant ces molécules. Elle concerne encore des populations polyclonales de molécules bispécifiques comprenant des populations de molécules bispécifiques présentant des spécificités de reconnaissance d'antigène différentes. De telles populations polyclonales de molécules bispécifiques peuvent être utilisées en ciblage d'épitopes multiples d'une molécule antigénique pathogène et/ou de variants multiples d'une molécule antigénique pathogène.

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