C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2483475
Provided are bispecific molecules that are characterized by having at least a first binding domain which binds T-cell immune response cDNA 7 (TIRC7) and a second binding domain which binds HLA-(Human Leukocyte associated Antigen); and optionally comprising further functional domains. Furthermore, compositions comprising said bispecific molecules and their use in methods of diagnosis and treating immune response related and other diseases including tumors are described.
L'invention concerne des molécules bispécifiques caractérisées en ce qu'elles comportent au moins un premier domaine de liaison pour la liaison avec l'ADNc 7 de réponse immunitaire des lymphocytes T (TIRC7) et un second domaine de liaison pour la liaison avec les antigènes leucocytaires humains (HLA); et éventuellement d'autres domaines fonctionnels. L'invention concerne également des compositions qui renferment lesdites molécules bispécifiques, et leur utilisation dans le cadre de procédés de diagnostic et de traitement de maladies liées aux réponses immunitaires et d'autres maladies, y compris les tumeurs.
Genpat77 Pharmacogenetics Ag
Sim & Mcburney
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