Bispecific monoclonal antibody, its production and use

Details Bispecific monoclonal antibody, its production and use Bispecific monoclonal antibody, its production and use

C - Chemistry, Metallurgy

12

P

167/139, 195/1.1

C12P 21/08 (2006.01) A61K 31/535 (2006.01) A61K 47/48 (2006.01) C07K 16/14 (2006.01) C07K 16/30 (2006.01) C07K 16/44 (2006.01) C07K 16/46 (2006.01) C12N 5/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2006408

ABSTRACT A bispecific monoclonal antibody to an ansamitocin derivative and a target antigen, particularly tumor-associated antigen, can carry an ansamitocin derivative in a stable and inactive form at other sites than the target and release the active-form ansamitocin derivative at the target site, so that an anticancer agent having excellent durability and selectivity with little adverse action can be prepared using the bispecific monoclonal antibody and ansamitocin derivatives.

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