Bisphenylsulfanyl and sulphonate compounds and use thereof...

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 321/30 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/24 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/4402 (2006.01) A61K 31/47 (2006.01) C07C 317/22 (2006.01) C07C 323/20 (2006.01) C07C 323/21 (2006.01) C07D 207/00 (2006.01) C07D 209/02 (2006.01) C07D 213/75 (2006.01) C07D 215/00 (2006.01) C07D 233/00 (2006.01) C07D 239/02 (2006.01)

Patent

CA 2460313

Provided herein are compounds and compositions that modulate the type 6 peroxisome proliferator-activated receptor (PPAR.sigma.). The subject compounds have the formula R1O2C-CR a R b-Y Ar1-X-Ar2-Z1-Z2-Ar3 wherein X is S(O)m, where the subscript m is an integer from 0 to 2; Y is 0; Z1 and Z2 are independently selected from the group consisting of O, (CR'R")n, and N(R"), where the subscript n is an integer from 1 to 2 and each R' and R" is hydrogen; Ar1 and Ar2 are independently naphthyl or phenyl, optionally substituted by halogen, and (C1-C4)alkyl; Ar3 is phenyl substituted by trifluoromethyl; R1 is hydrogen; and R a and R b are each hydrogen, or pharmaceutically acceptable salts thereof. Uses of the compounds and compositions, for instance, to treat a condition or disorder responsive to PPAR.sigma. modulation, such as hypercholesterolemia, among other conditions or disorders, or to elevate high density lipoprotein (HDL) cholesterol levels, are also provided herein.

L'invention concerne des composés, des compositions et des procédés utiles dans le traitement de troubles métaboliques, de maladies inflammatoires et du cancer. L'invention concerne en particulier des composés modulant l'expression et/ou la fonction de protéines intervenant dans le métabolisme lipidique, l'inflammation et la prolifération cellulaire. Ces composés sont des composés biaryles liés.

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