C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 1/00 (2006.01) A61K 31/66 (2006.01) C07F 9/38 (2006.01) C07F 9/655 (2006.01) C07J 41/00 (2006.01) C07J 43/00 (2006.01) C07J 51/00 (2006.01) C07J 73/00 (2006.01)
Patent
CA 2086026
HOE 91/S 037 K Abstract of the Disclosure A compound represented by the general formula: Image (I) wherein A-O-denotes a residue of a compound having an estrogenic activity; R1 denotes H or a C1-C6 alkyl group; X denotes a single bond, a C1-C10 alkylene group or a group of the formula Image Image ' or Image wherein R2 denotes H or a C1-C5 alkyl group; Z denotes a nitro group or a halogen; n is an integer of 3 to 12; k is an integer of l to 5; L is an integer of 0 to 5; and q is an integer of 1 to 3, and physiologically acceptable salts thereof. The compounds have a high affinity to bone tissues, and the compounds per se and metabolites thereof show significant therapeutic effect on bone diseases such as osteoporosis, rheumatoid arthritis and osteoarthritis.
Inazu Mizuho
Sugioka Tatsuo
Bereskin & Parr
Hoechst Japan Limited
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