Bisphosphonate squalene synthetase inhibitors and method

Details Bisphosphonate squalene synthetase inhibitors and method Bisphosphonate squalene synthetase inhibitors and method

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/40 (2006.01) C07F 9/655 (2006.01) C07F 9/6574 (2006.01)

Patent

CA 2067967

HX37 Abstract BISPHOSPHONATE SQUALENE SYNTHETASE INHIBITORS AND METHOD Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosyn- thesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are provided which have the structure Image and analogs thereof, wherein R1, R2, R3 and R4 are the same or different and are H, lower alkyl, a metal ion or a prodrug ester; R5 is H, halogen or lower alkyl; Zq is substituted alkenyl, substituted alkynyl, mixed alkenyl-alkynyl or substituted phenylalkyl, or substituted biphenylalkyl, alkyl- phenylalkyl or alkyl, including all stereoisomers thereof. New methods for using such compounds to inhibit cholesterol biosynthesis are also provided.

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