Bisphosphonic acid derivative and compound thereof labeled...

C - Chemistry – Metallurgy – 07 – F

Patent

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Details

C07F 9/38 (2006.01) A61K 51/00 (2006.01) A61K 51/04 (2006.01) C07B 59/00 (2006.01) C07F 13/00 (2006.01) C07K 5/083 (2006.01)

Patent

CA 2322936

An object of the present invention is to provide a bisphosphonic acid derivative and said bisphosphonic acid derivative being labeled with a radioactive nuclide, which has properties of rapid accumulation to the bone and rapid urinary excretion. The present invention relates to a bisphosphonic acid derivative and said bisphosphonic acid derivative being labeled with a radioactive nuclide, which is represented by the following general formula (1), R-Y-A (1) wherein A is a bisphosphonic acid or a salt thereof, having P-C-P bond; Y is a bonding portion such as a methylene, an amido etc.; R is a group of any one of a polyaminopolycarboxylic acid, an aliphatic carboxylic acid, a mercaptoacetylpolyamino acid or its derivatives and a compound represented by the formula (2), Image X is a halogen atom or an isotope thereof or an alkyl tin; Z is a group of any one of compounds of an aminocarboxylic acid, an alkylcarboxylic acid or a substituted-alkylcarboxylic acid, an alkylsulfonic acid or a substituted-alkylsulfonic acid.

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