C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/44 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2293713
Novel compounds of formula (1.0) or (2.0) are disclosed. Also disclosed is a method of inhibiting farnesyl protein transferase function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of said formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Also disclosed is a method of effecting an anti-allergic response by administering the compounds.
La présente invention concerne de nouveaux composés représentés par la formule (1.0) ou (2.0). La présente invention concerne également un procédé d'inhibition de la fonction de farnésyl protéine transférase et donc d'inhibition de la croissance anormale des cellules. Le procédé consiste à administrer un composé de la formule ci-dessus à un système biologique. Le procédé inhibe, en particulier, la croissance anormale des cellules chez un mammifère tel qu'un homme. La présente invention concerne, en outre, un procédé permettant de développer une réponse immunitaire anti-allergique en administrant lesdits composés.
Cooper Alan B.
Desai Jagdish A.
Girijavallabhan Viyyoor M.
Saksena Anil K.
Wang James J.-S.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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