Bisulfate salt of hiv protease inhibitor

Details Bisulfate salt of hiv protease inhibitor Bisulfate salt of hiv protease inhibitor

C - Chemistry, Metallurgy

07

D

C07D 213/02 (2006.01) A61K 31/44 (2006.01) C07D 213/42 (2006.01)

Patent

CA 2317736

The present invention provides the crystalline bisulfate salt of formula (II) which is found to have unexpectedly high solubility/dissolution rate and oral bioavailability relative to the free base form of this azapeptide HIV protease inhibitor compound.

La présente invention concerne un sel de bisulfate cristallisé de la formule (II) présentant un coefficient de solubilité et une vitesse de dissolution élevés inattendus, ainsi qu'une biodisponibilité orale relativement à la forme de la base libre du composé azapeptide inhibiteur de la protéase du VIH.

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