Bivalent erbb ligand binding molecules and methods for their...

Details Bivalent erbb ligand binding molecules and methods for their... Bivalent erbb ligand binding molecules and methods for their...

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01) C07K 1/00 (2006.01)

Patent

CA 2642516

A new bivalent ErbB-based ligand binding molecule is disclosed along with its method of preparation and use. The binding molecule can be a protein expressed from a recombinant DNA molecule. The protein can contain two extracellular domains of an ErbB receptor that both bind to ErbB receptor ligands. These binding molecules act as traps to bind and sequester ligands, thus making them unavailable for binding to cellular ErbB receptors.

La présente invention concerne une molécule de liaison de ligand ErbB bivalente ainsi que son procédé de préparation et son utilisation. La molécule de liaison peut être une protéine exprimée à partir d'une molécule d'ADN recombiné. La protéine peut contenir deux domaines extracellulaires d'un récepteur ErbB qui se lient tous deux aux ligands du récepteur ErbB. Ces molécules de liaison agissent telles des pièges qui lient et emprisonnent les ligands, les rendant ainsi indisponibles pour toute liaison avec les récepteurs cellulaires ErbB.

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