Bivalent smac mimetics and the uses thereof

Details Bivalent smac mimetics and the uses thereof Bivalent smac mimetics and the uses thereof

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/407 (2006.01) A61K 31/4192 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2651206

The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

L'invention concerne des agents mimétiques bivalents de la protéine Smac qui agissent en tant qu'inhibiteurs de l'inhibiteur des protéines de l'apoptose. L'invention concerne également l'utilisation de ces agents mimétiques pour induire une mort cellulaire programmée et pour sensibiliser les cellules à des inducteurs de l'apoptose.

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