Bladder cancer biomarkers and uses thereof

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01)

Patent

CA 2607243

The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with bladder cancer as compared with individuals without bladder cancer. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing bladder cancer. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for bladder cancer.

L'invention concerne l'identification et le choix de nouveaux biomarqueurs ainsi que l'identification et le choix de nouvelles combinaisons de biomarqueurs qui s'expriment différemment chez les individus selon qu'ils sont atteints ou non d'un cancer de la vessie. L'invention concerne également des polynucléotides et des protéines qui s'hybrident spécifiquement et/ou sélectivement avec les produits de ces biomarqueurs ainsi que des kits contenant lesdits polynucléotides et protéines pour diagnostic du cancer de la vessie. De plus, l'invention porte sur des polynucléotides et des protéines qui, en s'hybridant spécifiquement et/ou sélectivement avec les produits de ces biomarqueurs, permettent de surveiller une régression de la maladie chez un individu et d'apprécier l'efficacité de régimes thérapeutiques. Sont également décrites des méthodes d'utilisation des produits biomarqueurs pour l'identification de nouvelles cibles thérapeutiques pour le cancer de la vessie.

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