Bladder nuclear matrix proteins and their use in detecting...

Details Bladder nuclear matrix proteins and their use in detecting... Bladder nuclear matrix proteins and their use in detecting...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2209314

Nuclear matrix proteins (NMPs) which are characterized by a defined expression in bladder tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy, and treating cell proliferative disorders of the bladder. Also provided are substantially purified polypeptides and polypeptide sequences encoding the NMPs of the invention.

Cette invention se rapporte à des protéines matricielles nucléaires (NMP) qui se caractérisent par une expression définie au niveau du tissu de la vessie. Ces protéines matricielles nucléaires s'avèrent être des marqueurs utiles dans le diagnostic et la surveillance de l'état de malignité, et dans le traitement des troubles liés à une prolifération cellulaire. L'invention se rapporte également des polypeptides et à des séquences polypeptidiques, sensiblement purifiés, codant les protéines matricielles nucléaires de l'invention.

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