Blk genes, gene products and uses thereof in apoptosis

Details Blk genes, gene products and uses thereof in apoptosis Blk genes, gene products and uses thereof in apoptosis

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2324445

Genes and gene products of Blk, a pro-apoptotic protein in the Bcl-2 gene family, are provided. Effector molecules that either increase or decrease Blk and thus promote or inhibit apoptosis are described. The Blk genes and proteins and effector molecules may be used to treat diseases that have unwanted cell proliferation used to promote cell growth.

L'invention concerne des gènes et produits géniques de Blk, une protéine pro-apoptotique de la famille des gènes Bcl-2. L'invention concerne également des molécules effectrices qui augmentent ou réduisent Blk et de ce fait favorisent ou inhibent une apoptose. On peut utiliser les gènes et protéines Blk et les molécules effectrices dans le traitement d'affections présentant une prolifération cellulaire non voulue utilisée pour favoriser la croissance cellulaire.

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