Block copolymer reduced in impurity content, polymeric...

Details Block copolymer reduced in impurity content, polymeric... Block copolymer reduced in impurity content, polymeric...

C - Chemistry, Metallurgy

08

G

C08G 69/40 (2006.01) A61K 31/704 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C08G 73/10 (2006.01)

Patent

CA 2450448

A process for purification which permits satisfactory removal of impurities from a block copolymer consisting essentially of polyethylene glycol and poly(acidic amino acid) and is suitable for the production of a polymeric carrier having a pharmaceutically acceptable purity; a process for producing such a polymeric carrier; a block copolymer reduced in impurity content; a polymeric carrier as described above; pharmaceutical preparations in polymeric form, produced by the use of the carrier; and a method of subjecting polyethylene glycol and poly(acidic amino acid)- which are impurities contained in the block copolymer- to treatment with either an ion-exchange resin or a partition/adsorption resin and then determining the quantities of them with a gel filtration column.

L'invention concerne : un procédé de purification qui permet d'obtenir une élimination satisfaisante des impuretés d'un copolymère bloc constitué essentiellement de polyéthylène glycol et de poly(acide aminé acide) et qui convient pour la production d'un support polymère contenant une pureté pharmaceutiquement acceptable ; un procédé de production dudit support polymère ; un copolymère bloc à taux d'impuretés réduit ; un support polymère tel que décrit ci-dessus ; des préparations pharmaceutiques sous forme polymère, obtenues au moyen du support ; et une méthode consistant à soumettre le polyéthylène glycol et le poly(acide aminé acide) qui sont des impuretés contenues dans le copolymère bloc à un traitement soit à base d'une résine échangeuse d'ions, soit à base d'une résine de séparation/adsorption, puis à déterminer les quantités à l'aide d'une colonne de gel de filtration.

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