Blockade of gamma-secretase activity to promote myelination...

Details Blockade of gamma-secretase activity to promote myelination... Blockade of gamma-secretase activity to promote myelination...

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01)

Patent

CA 2646140

Methods are provided for enhancing myelination. Myelination is enhanced by administration of agents that are inhibitors of .gamma.-secretase. Methods of screening for pharmaceutically active compounds that enhance myelination, and for genes involved in myelination are also provided.

L'invention concerne des procédés de renforcement de la myélinisation. La myélinisation est renforcée par l'administration d'agents qui sont des inhibiteurs de la .gamma.-sécrétase. La présente invention concerne également des procédés de criblage de composés pharmaceutiquement actifs qui renforcent la myélinisation ainsi que de gènes impliqués dans la myélinisation.

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