Blockers of the quorum sensing system of gram-negative bacteria

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 333/38 (2006.01) C07D 207/32 (2006.01) C07D 209/08 (2006.01) C07D 209/42 (2006.01) C07D 209/86 (2006.01) C07D 211/02 (2006.01) C07D 211/34 (2006.01) C07D 211/60 (2006.01) C07D 215/08 (2006.01) C07D 231/12 (2006.01) C07D 231/40 (2006.01) C07D 273/00 (2006.01) C07D 275/02 (2006.01) C07D 295/18 (2006.01) C07D 307/68 (2006.01)

Patent

CA 2526904

The present invention relates to the use of compounds of the general Formula (XIII), wherein A7 is C=O, C=S, S02, CH-OR13, C=NR12 or CH2-CHOR13; A8 is C(R14 )2, 0, S, or NR 12; A9 is C=O, C=S, S02, CH-OR13, C=NR12 or CH2-CHOR13 m is 0, or 1 q is 0, or I r is 0, or 1 R12 is H, CH3, CH2-CH3, C6H5, OCH3, OCH2- CH3, OH, or SH; R13 is H, CH3, or CH2-CH3; R14 is H, alkyl, alkoxy, OH, or SH;

La présente invention concerne l'utilisation de composés de formule générale (XIII), dans laquelle A?7¿ désigne C=O, C=S, S0¿2?, CH-OR?13¿, C=NR?12¿ ou CH¿2?-CHOR?13¿ ; A?8¿ désigne C(R?14¿)¿2?, 0, S ou NR?12¿ ; A?9¿ désigne C=O, C=S, SO¿2?, CH-OR?13¿, C=NR?12¿ ou CH¿2?-CHOR?13¿ ; m représente 0 ou 1 ; q représente 0 ou 1 ; r représente 0 ou 1 ; R?12¿ désigne H, CH¿3?, CH¿2?-CH¿3?, C¿6?H¿5?, OCH¿3?, OCH¿2?-CH¿3?, OH ou SH ; R?13¿ désigne H, CH¿3? ou CH¿2?-CH¿3? et R?14¿ désigne H, alkyle, alcoxy, OH ou SH.

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