Blocking induction of tetrahydrobiopterin to block induction...

Details Blocking induction of tetrahydrobiopterin to block induction... Blocking induction of tetrahydrobiopterin to block induction...

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/40 (2006.01) A61K 31/4045 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2075346

?TRACT OF THE DISCLOSURE Guanosine triphosphate pathway tetrahydrobiopterin synthesis antagonist and/or pterin salvage pathway tetrahydrobiopterin synthesis antagonist are administered to inhibit nitric oxide synthesis from arginine in vascular smooth muscle cells in a subject in need of such inhibition (e.g. for prophylactic or curative effect for cytokine-induced hypotension or for restoration of vascular contractile sensitivity to pressor agents in the treatment of such hypotension).

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