A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) G01N 33/50 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2402530
The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that CD99 mediates TEM, because blocking CD99 on either endothelial cells or monocytes bloks migration 80-90 %. In conjunction with PECAM inhibitors, TEM blockade approaches 100 %. CD99 is involved in a step in TEM that is distal to the step controlled by PECAM.
La présente invention concerne des méthodes et des compositions qui permettent de moduler la migration transendothéliale (TEM) des leucocytes. En particulier, l'inhibition de la TEM peut constituer une approche thérapeutique puissante pour le traitement d'affections inflammatoires. L'invention concerne en particulier la découverte selon laquelle CD99 intervient indirectement dans la TEM, car le blocage de CD99 dans les cellules endothéliales ou les monocytes inhibe la migration à 80-90 %. Conjointement aux inhibiteurs PECAM, l'inhibition de la TEM approche les 100 %. CD99 intervient dans une étape de TEM distale de l'étape régulée par PECAM.
Muller William A.
Schenkel Alan R.
Cornell Research Foundation Inc.
Robic
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