Blocking mesothelin peptide fragments

Details Blocking mesothelin peptide fragments Blocking mesothelin peptide fragments

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2745798

The present invention provides mesothelin peptide fragments corresponding to the CA125 binding site of mesothelin. The peptide fragments find use in disrupting the binding interaction between mesothelin and CA 125, for example, in the treatment and prevention of cancers that require the interaction of mesothelin and CA125 for growth, progression and/or metastasis.

La présente invention porte sur des fragments peptidiques de mésothéline correspondant au site de liaison à CA125 de la mésothéline. Les fragments peptidiques sont utilisés dans la perturbation de l'interaction de la liaison entre la mésothéline et CA125, par exemple dans le traitement et la prévention de cancers dont la croissance, la progression et/ou les métastases nécessitent l'interaction de la mésothéline et de CA125.

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