Blocking peptide for inflammatory cell secretion

Details Blocking peptide for inflammatory cell secretion Blocking peptide for inflammatory cell secretion

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 31/675 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2452123

The present invention includes methods of modulating cellular secretory processes. More specifically the present invention relates to modulating the release of inflammatory mediators. Additionally, the present invention discloses an intracellular signaling mechanism that regulates airway mucin secretion as well as illustrating several novel intracellular targets for pharmacological intervention in disorders involving aberrant secretion of respiratory mucins and/or secretion of inflammatory mediators from membrane- bound vesicles.

L'invention concerne des procédés permettant de moduler les processus sécrétoires des cellules, et plus spécifiquement des procédés permettant la modulation de la libération des médiateurs inflammatoires. L'invention concerne en outre un mécanisme de signalisation intracellulaire qui régule la sécrétion de mucine dans les voies respiratoires, ainsi que différentes nouvelles cibles intracellulaires d'intervention pharmacologique pour les troubles associées à une sécrétion anormale de mucines respiratoires et/ou à une sécrétion de médiateurs inflammatoires par les vésicules membranaires.

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