Blocking the migration or metastasis of cancer cells by...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/704 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07J 63/00 (2006.01) C07H 15/256 (2006.01) C07J 53/00 (2006.01)

Patent

CA 2676791

This invention provides methods, processes, compounds and compositions for modulating the gene expression or secretion of adhesion proteins or their receptors to cure disease, wherein the modulating comprises positive and negative regulating; wherein comprises inhibiting cancer growth, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, Myosin, vitronectin, collagen, laminin, Glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, CD 54, CAM, elastin and FAK; wherein the methods, processes, compounds and compositions are also for anti-angiogenesis; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer.

L'invention concerne des méthodes, des processus, des composés et des compositions permettant de moduler l'expression génique ou la sécrétion de protéines d'adhésion ou de leurs récepteurs pour traiter des maladies, cette modulation comprenant une régulation positive et négative. Les méthodes selon l'invention consistent à inhiber le développement du cancer, les protéines d'adhésion ou leurs récepteurs comprenant les fibronectines, la famille des intégrines, les myosines, les vitronectines, les collagènes, les laminines, les protéines de surface cellulaire de glycosylation, les polyglycanes, les cadhérines, les héparines, les tenascine, CD 54, CAM, les élastine et FAK. Les méthodes, processus, composés et compositions selon l'invention sont également utiles dans l'anti-angiogenèse. Les cancers pouvant être traités par la mise en AEuvre de la présente invention comprennent le cancer du sein, le cancer des leucocytes, le cancer du foi, le cancer de l'ovaire, le cancer de la vessie, le cancer de la prostate, le cancer de la peau, le cancer des os, le cancer du cerveau, la leucémie, le cancer du poumon, le cancer du colon, le cancer du SNC, le mélanome, le cancer du rein ou le cancer du col de l'utérus.

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