Blood-brain barrier epitopes and uses thereof

Details Blood-brain barrier epitopes and uses thereof Blood-brain barrier epitopes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2623841

The invention features a method of identifying an agent and generating an antibody that can cross the blood bram barrier, through the use of novel antigen isoforms of transmembrane domain protein 30A (TMEM30A) This is useful in establishing mechanisms of transmigration across the blood-bram barrier. These antigens are enriched in bram endothelium compared to other endothelial cells and may have better selectivity and capacity for bram delivery compared to transferrin and insulin receptors One antigen is TMEM30A.

Selon l'invention, l'utilisation d'une combinaison de techniques de biologie cellulaire, de biochimie, d'immunochimie et de biologie moléculaire, a permis d'identifier des nouveaux antigènes associés à la barrière hématoencéphalique. Cette utilisation permet d'établir des mécanismes de transmigration à travers la barrière hématoencéphalique. Lesdits antigènes sont enrichis dans l'endothélium cérébral en comparaison avec d'autres cellules endothéliales et ils peuvent présenter une aptitude à la sélection et une capacité d'administration cérébrale meilleures par rapport aux récepteurs de la transferrine et de l'insuline. Un antigène est TMEM30A.

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