A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C12N 5/071 (2010.01) C12N 5/078 (2010.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 39/38 (2006.01) A61P 7/06 (2006.01) C07K 16/28 (2006.01) C12N 5/00 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2441566
Methods and compositions for stimulating the growth, proliferation, differentiation and/or mobilization of stem and/or progenitor cells are described. The method involves administering an effective amount of a substance which can activate the CD163 hemoglobin scavenger receptor signal transduction pathway. The methods and compositions are useful in stimulating hematopoiesis and in treating a wide range of conditions including cytopenias, anemias and for use in preparing cells for transplantation.
La présente invention concerne des procédés et compositions permettant de stimuler la croissance, la prolifération, la différentiation et/ou la mobilisation de cellules souches et/ou progénitrices. Le procédé fait intervenir l'administration d'une quantité suffisante d'une substance capable d'activer le chemin de transduction du signal destiné au récepteur CD163 du détritophage de l'hémoglobine. Ces procédés et compositions conviennent pour la stimulation de l'hématopoïèse et le traitement de divers états tels que la cytopénie et les anémies, et pour la préparation des cellules à la transplantation.
Bell David
Matthews Kathryn Emma
Mueller Susan
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hemosol Inc.
Therapure Biopharma Inc.
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