Blood cell typing and compatibility test by solid phase...

Details Blood cell typing and compatibility test by solid phase... Blood cell typing and compatibility test by solid phase...

A - Human Necessities

61

B

167/39

A61B 10/00 (2006.01) G01N 33/80 (2006.01)

Patent

CA 1089359

ABSTRACT OF THE DISCLOSURE A solid-phase blood typing procedure is described based upon either agglutination or immune lysis. In this in- vention, a monolayer of ceils is irreversibly (e.g., covalently) bound to a solid matrix, and thereafter a serum containing antibodies is brought into contact with the bound cell layer. Immunoadsorption of antibodies by the bound cells occurs where the antigens of the cell membranes and the antibodies in the serum are complementary to each other. This antibody-sensitized monolayer of blood cells can either bind a second layer of blood cells carrying complementary antigen (solid-phase agglutination) or undergo lysis in the presence of serum complement (solid- phase immune lysis). Carrying out these reactions with a mono- layer of blood cells bound to a solid matrix allows quantitative evaluation of results by such standard instrumentable proce- dures as densitometric scanning, radioisotope counting, etc. -1-

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