Blood clot-targeted nanoparticles

A - Human Necessities – 61 – K

Patent

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Details

A61K 51/12 (2006.01) A61B 5/055 (2006.01) A61B 8/00 (2006.01) A61K 9/107 (2006.01) A61K 9/14 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61K 49/14 (2006.01) A61K 49/16 (2006.01) A61K 49/18 (2006.01) A61K 49/22 (2006.01) A61K 51/00 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01)

Patent

CA 2491758

Emulsions comprising nanoparticles formed from high boiling perfluorochemical substances, said particles coated with a lipid/surfactant coating are made target-specific by directly coupling said nanoparticles to a targeting ligand. The nanoparticles may further include biologically active agents, radionuclides, and/or other imaging agents, and are used to image and/or lyse blood clots in human subjects.

L'invention concerne des émulsions comprenant des nanoparticules formées à partir de substances perfluorochimiques à point d'ébullition élevé, lesdites particules étant enrobées d'un revêtement lipide/tensioactif et spécifiques à une cible par le couplage direct desdites nanoparticules à un ligand de ciblage. Les nanoparticules peuvent comporter en outre des agents biologiquement actifs, des radionuclides et/ou d'autres agents d'imagerie, et servent à imager et/ou à lyser des caillots sanguins chez des patients humains.

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