Blood products for parenteral administration

Details Blood products for parenteral administration Blood products for parenteral administration

A - Human Necessities

61

K

167/114

A61K 35/16 (2006.01)

Patent

CA 1306943

ABSTRACT OF THE DISCLOSURE: There are disclosed blood products for parenteral administration which are essentially free of immune- modulating components, and methods for their production. The absence of immune-modulating components is expressed by the lack or absence of down-modulation of Fc receptors in the membrane of leukocytes. The expression of the receptors for the Fc fragment of immunoglobulin G in the membrane of monocytes, after interaction with a blood product preparation, is to be reduced not at all or by 30 % at most. The blood products are obtained - by molecular sieving of the blood products by gel permeation chromatography (gel filtration), or - by treatment of the blood products with a molecular sieve-like carrier material on which immune- modulating components are selectively adsorbed, or - by filtration of the blood products through filters having pore diameters of equal to, or smaller than, 10 nm.

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