Blood substitute based on hemoglobin

Details Blood substitute based on hemoglobin Blood substitute based on hemoglobin

C - Chemistry, Metallurgy

08

B

167/114, 260/210

C08B 31/12 (2006.01) A61K 47/48 (2006.01) C07K 14/805 (2006.01) C08B 31/00 (2006.01) C08B 37/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1055932

ABSTRACT OF THE DISCLOSURE A blood substitute or blood extender is prepared by chemically coupling hemoglobin with a polysaccharide material selected from dextran and hydroxyethyl starch, and having a molecular weight of from about 5,000 to about 2,000,000, to form a covalently bonded chemical complex. The complex has similar oxygen transporting abilities to hemoglobin, and has a much lower rate of renal excretion.

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