Blood substitutes

Details Blood substitutes Blood substitutes

C - Chemistry, Metallurgy

12

N

167/114, 195/1.2

C12N 15/12 (2006.01) A61K 35/14 (2006.01) A61K 38/42 (2006.01) C07K 14/805 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341286

Solutions of mutant hemoglobins having a lower oxygen affinity than that of native hemoglobin are used as blood substitutes. The mutant hemoglobins are preferably obtained by recombinant DNA techniques. Both alpha anal beta globin chains can now be so prepared, making possible the production of wholly artificial hemoglobin, whether conventional or mutant in form. Solutions of wholly artificial hemoglobins are also used as blood substitutes.

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