G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2729000
The present invention includes methods, systems and kits for distinguishing between active and latent mycobac-terium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosis, and distinguishing such patients from uninfected individuals, the method including the steps of obtaining a gene expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression mod-ules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the lev-els of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non- infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection.
L'invention porte sur des méthodes, systèmes et trousses permettant de distinguer entre des infections actives et latentes par le mycobacterium tuberculosis chez un patient suspecté d'être infectée par ladite bactérie, et de distinguer ledit patient d'individus non infectés. La méthode consiste à obtenir un ensemble de données d'expression du gène d'un échantillon de sang entier du patient, et à déterminer l'expression différentielle d'un ou plusieurs modules d'expression du gène de transcription qui permettent de distinguer entre des patients infectés et non infectés. L'ensemble de données démontre un changement global des niveaux de polynucléotides dans le ou les modules d'expression du gène de transcription par rapport à un patient correspondant non infecté, distinguant ainsi entre l'infection active et latente par le mycobacterium tuberculosis.
Banchereau Jacques F.
Berry Matthew
Chaussabel Damien
Kon Onn Min
O'garra Anne
Baylor Research Institute
Imperial College Healthcare Nhs Trust
Shapiro Cohen
The National Institute For Medical Research
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