A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/199
A61K 31/715 (2006.01) A61K 35/74 (2006.01)
Patent
CA 1204667
BLOOD TREATING AGENT ABSTRACT OF THE DISCLOSURE The present invention provides (1) a blood-treating material containing a lipopolysaccharide derived from cell walls of Gram-negative bacteria and immobilized by an insoluble carrier containing an amino group and/or a carboxyl group, and (2) a process for producing the blood-treating material in which a condensing agent is reacted with a mixture of the lipopolysacchar- ide and the insoluble carrier. Lipopolysaccharides have been known to exhibit antitumor effects against malignant tumors. However, they have not been used safely, since their fatal doses are very close to the minimum effective doses in the treatment of such tumors. The present invention makes it possible to reduce the lethal toxicity of the abovementioned lipopolysacchar- ides and provide a therapy for cancer, because the unique blood- treating material disclosed herein not only has antitumor effects similar to those of the lipopolysaccharides derived from the cell walls of Gram-negative bacteria but no fatal effects are observed at antitumor effective dosage levels.
438186
Katayama Yutaka
Kodama Masashi
Murakami Mutsuo
Tani Toru
Teramoto Kazuo
Smart & Biggar
Toray Industries Inc.
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