Blys fusion proteins for targeting blys receptor and methods...

Details Blys fusion proteins for targeting blys receptor and methods... Blys fusion proteins for targeting blys receptor and methods...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/415 (2006.01) C07K 14/525 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2595904

The present invention regards targeted BLyS polypeptides capable of binding to BLyS receptors and that deliver a cytotoxic agent, such as a cytotoxic peptide, for example. In particular aspects, the cytotoxic agent comprises at least part of rGelonin. These compositions are useful for treating, preventing, and/or monitoring therapy for a B-cell proliferative disorder.

La présente invention concerne des polypeptides BLyS ciblés qui peuvent se lier à des récepteurs de BLyS et qui délivrent un agent cytotoxique, par exemple, un peptide cytotoxique. Selon des aspects particuliers, l'agent cytotoxique comprend au moins une partie de of rGelonine. Ces compositions permettent de traiter, de prévenir et/ou de surveiller le traitement d'un trouble prolifératif des lymphocytes B.

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