Bmp-2 estrogen responsive element and methods of using the same

Details Bmp-2 estrogen responsive element and methods of using the same Bmp-2 estrogen responsive element and methods of using the same

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/565 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) A61L 27/38 (2006.01) A61P 19/10 (2006.01) C07H 21/04 (2006.01) C07K 14/51 (2006.01) C12N 15/18 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2497304

The invention relates to an isolated nucleic acid corresponding to BMP-2 regulatory region, or a fragment thereof comprising an estrogen responsive element, vector comprising the same and cells, which comprises said vector. In another embodiment, the invention provides methods of identifying an estrogen agonist, antagonist and a therapeutic agent in another embodiment the invention provides methods of treating conditions which are associated with estrogen insufficiency or with lack of response to external estrogen or agonists thereof.

Cette invention se rapporte à un acide nucléique isolé correspondant à la région régulatrice de BMP-2, ou à un fragment de celui-ci, comprenant un élément réagissant aux oestrogènes, un vecteur comprenant cet élément et des cellules comprenant ce vecteur. Dans un autre mode de réalisation, cette invention concerne des procédés pour identifier un agoniste, un antagoniste et un agent thérapeutique des oestrogènes. Dans un autre mode de réalisation, cette invention concerne des procédés servant à traiter des états qui sont associés à une insuffisance d'oestrogènes ou à un manque de réaction aux oestrogènes externes ou à des agonistes de ceux-ci.

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