Bombesin analog peptide antagonist conjugates

Details Bombesin analog peptide antagonist conjugates Bombesin analog peptide antagonist conjugates

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 51/08 (2006.01)

Patent

CA 2717427

To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I): [A-(B) n ] x -C, wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-tenninal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an integer from 1 to 3 and n is an integer from 1 to 6.

Linvention concerne un conjugué antagoniste dun peptide de lanalogue de la bombésine, comme agent de diagnostic et médicament thérapeutique, de la formule générale (I) : [A-(B)n]x-C, dans laquelle A représente un chélateur de métaux qui comprend au moins un métal radionucléide, B représente un espaceur lié à un N-terminal de C ou une liaison covalente et C représente un antagoniste dun peptide de lanalogue de la bombésine qui possède une séquence telle que revendiquée, où en outre x est un nombre entier de 1 à 3 et n est un nombre entier de 1 à 6.

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