Bombesin analogs

Details Bombesin analogs Bombesin analogs

C - Chemistry, Metallurgy

07

K

C07K 7/02 (2006.01) A61K 38/08 (2006.01) C07K 5/02 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2109322

Disclosed are Agonists and Antagonist of bombesin which are derivatives of naturally occurring bombesin possessing a methyl sulfide or a methyl amide bond connecting the two amino acids on he carboxy terminal end. Agonist and antagonist ac- tivities are confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions. Use of these peptides include stimulating or antagonizing growth of tis- sues, especially lung, and a means for effecting treatment for digestional disorders. Treatment comprises administering to a pa- tient in need thereof, an effective amount of a bombesin analog.

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